Metformin reverts aortic calcifications and elastin loss induced by an experimental metabolic syndrome.

Metabolic syndrome (MetS) is associated with osteogenic transdifferentiation of vascular smooth muscle cells (VSMCs) and accumulation of arterial calcifications (ACs). Metformin (MET) inhibits this transdifferentiation in vitro. Here, we evaluate the in vivo efficacy of oral MET to reduce AC in a model of MetS.

Metformin treatment prevents experimental metabolic syndrome-induced femoral bone marrow adiposity in rats.

Objective.: Motivation for the study. Most research supports a negative association between metabolic syndrome and bone health, although there is an overall lack of consensus.

Incidence and predictive factors of postoperative hypocalcaemia according to type of thyroid surgery in older adults.

Purpose: Transient hypocalcaemia after thyroid surgery and its possible predictors have not been extensively described in the elderly. This study aimed to establish the frequency of postsurgical transient hypocalcaemia according to the extent of thyroid surgery in older adults and to assess mineral metabolism biochemical parameters as its predictors.

Methods: All patients ≥60 years undergoing thyroid surgery were prospectively included.