Parallel single-cell metabolic analysis and extracellular vesicle profiling reveal vulnerabilities with prognostic significance in acute myeloid leukemia.

Acute myeloid leukemia (AML) is an aggressive disease with a high relapse rate. In this study, we map the metabolic profile of CD34(CD38) AML cells and the extracellular vesicle signatures in circulation from AML patients at diagnosis. CD34 AML cells display high antioxidant glutathione levels and enhanced mitochondrial functionality, both associated with poor clinical outcomes.

The Role of Natriuretic Peptides in Pericardial Fluid in Predicting Cardiovascular Disorders: A Systematic Review.

Atrial and ventricular natriuretic peptides play an important role in the neurohormonal regulation of cardiac function. Plasma levels of these peptides may aid in the diagnosis and prognosis of different cardiac disorders, such as congestive heart failure, ischemic heart disease, and atrial fibrillation. However, the association between elevated pericardial fluid levels of natriuretic peptides and these clinical conditions has not been proven.

Parents' perspectives and behaviors regarding their child's access to alcohol: Variation by race/ethnicity, socioeconomic status, and neighborhood.

Background: Setting rules about alcohol use and minimizing its availability in the home are known effective parent-level strategies for reducing underage drinking risk. However, parents' restrictions and their perceptions of their child's alcohol access have rarely been considered in combination (e.g.

Measurement equivalence of the Marijuana Effect Expectancies Questionnaire-Brief across sex, race/ethnicity, and their co-occurring social identities for Black, Latinx, and non-Latinx white youth in the Adolescent Brain Cognitive Development (ABCD) Study.

Objective: The primary aim of this study was to assess and adjust for measurement non-equivalence (bias) by sex, race/ethnicity, and co-occurring social identities (sex x race/ethnicity) for the Marijuana Effect Expectancies Questionnaire-Brief (MEEQ-B) among Black, Latinx, and Non-Latinx white youth. The second aim was to determine how group comparisons change after accounting for possible measurement bias.

Method: Black, Latinx, and Non-Latinx white youth from the Adolescent Brain and Cognitive Development Study Follow-up 3 (n=8,982; mean age=12.