Publications by authors named "C E Peyton"
Background: The increasing clinical use of combining structural MRI (sMRI) with General Movements Assessment (GMA) or Hammersmith Infant Neurological Exam (HINE) before five months corrected age (CA) for early diagnosis of cerebral palsy (CP) lacks sufficient prognostic data for children with CP, especially those with Gross Motor Function Classification System (GMFCS) I.
Objective: Evaluate the predictive value of sMRI, GMA, and HINE individually and in combination for early CP diagnosis and assess accuracy across varying GMFCS levels in a regional cohort of preterm infants.
Methods: We performed sMRI between 39-44 weeks postmenstrual age and GMA and HINE between 12-18 weeks CA in 395 preterm infants born at ≤32 weeks' gestation across five NICUs in Greater Cincinnati.
Article Synopsis
- Researchers assessed circulating tumor DNA (ctDNA) as a biomarker for monitoring cancer treatment in patients with various renal cell carcinoma (RCC) types, finding it could improve clinical outcomes.
- The study involved 92 patients undergoing treatment, monitoring ctDNA changes and their association with progression-free survival (PFS), revealing that patients with serial ctDNA negativity had better PFS compared to those who remained ctDNA positive.
- Results indicate that regular ctDNA monitoring can provide valuable prognostic information during treatment or surveillance, showing strong correlation with patient outcomes.
Article Synopsis
- There is limited data on how often testicular germ cell tumors (TGCT) occur alongside venous tumor thrombus (VTT), and the study aims to provide insights on this rare condition and its management.
- Researchers analyzed records from the IBM Marketscan database, identifying a small prevalence of TGCT with VTT and gathered expert insights from surgeons on the patient management practices at multiple centers.
- Findings showed that approximately 0.3% to 3.1% of TGCT cases involved VTT, with surgical options being the primary treatment, emphasizing the complexity of managing this combination and the need for a multidisciplinary approach.