Publications by authors named "C E Pennell"

Objective: The objective of this review is to identify international and Nova Scotian standards of care, CPGs, and policies informing equitable health care.

Introduction: The lack of attention given to intersectional health care needs of diverse populations perpetuates health inequities among under-served groups, creating an urgent need for health care reform globally.

Inclusion Criteria: This scoping review will include standards of care, CPGs, and policies focusing on equity-related health indicators.

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Objectives: Research to develop early screening tools to determine an individual's risk of developing adult-onset disease is a growing field. Expectant parents may find themselves with an option in the future to undergo screening to determine not only genetic abnormalities in their child but also their risk of developing adult-onset non-communicable diseases (NCD) such as hypertension, obesity or hypercholesterolaemia. To ensure acceptability and feasibility of new screening tools researchers must work in partnership with healthcare consumers to discern consumers' current understanding and acceptance of these technologies in research and the potential for clinical applications.

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Background: Research in the developmental origins of health and disease provides compelling evidence that adverse events during the first 1000 days of life from conception can impact life course health. Despite many decades of research, we still lack a complete understanding of the mechanisms underlying some of these associations. The Newcastle 1000 Study (NEW1000) is a comprehensive, prospective population-based pregnancy cohort study based in Newcastle, New South Wales, Australia, that will recruit pregnant women and their partners at 11-14 weeks' gestation, with assessments at 20, 28, and 36 weeks; birth; 6 weeks; and 6 months, in order to provide detailed data about the first 1000 days of life to investigate the developmental origins of noncommunicable diseases.

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Background: It is unclear whether sex differences in behavior arising from birth weight (BW) are genuine because of the cross-sectional nature and potential confounding in previous studies. We aimed to test whether sex differences associated with BW phenotype were reproducible using a Mendelian randomization approach, i.e.

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Article Synopsis
  • - This study analyzed how pregnancy complications and birth outcomes affect telomere length in children at age 17, using data from the Raine cohort study in Western Australia, which followed 2900 children over the years.
  • - The research found no overall differences in telomere length based on individual maternal or birth outcomes, but females exposed to adverse conditions during pregnancy exhibited shorter telomeres compared to those born without complications.
  • - Interestingly, while females from pre-eclamptic pregnancies specifically showed significantly shorter telomeres, no such effects were observed in males; this highlights the need for further studies to investigate the factors influencing telomere length in genders separately.
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