Genomic analysis through various platforms is an essential tool for determining prognosis and treatment in a significant subgroup of early-stage breast cancer patients with hormone receptor-positive and human epidermal growth factor receptor 2 (HER2)-negative status. Additionally, combined clinical and pathological characteristics can accurately predict the recurrence score (RS), as demonstrated by the University of Tennessee risk nomogram. In this study, we aimed to identify classical clinical-pathological factors associated with high RS in a local population, including modern parameters such as current abemaciclib treatment recommendations, HER2-low status, different Ki-67 cutoff values, and samples obtained from secondary primary tumours.
View Article and Find Full Text PDFThis narrative review aims to clarify the role of tertiary lymphoid structures in breast cancer. We examine their development, composition, and prognostic value, and current ways of recognizing them. A comprehensive literature review was performed using the PubMed/Medline, Scopus, and EMBASE databases.
View Article and Find Full Text PDFWe develop a new method for the construction of one-dimensional integrable Lindblad systems, which describe quantum many body models in contact with a Markovian environment. We find several new models with interesting features, such as annihilation-diffusion processes, a mixture of coherent and classical particle propagation, and a rectified steady state current. We also find new ways to represent known classical integrable stochastic equations by integrable Lindblad operators.
View Article and Find Full Text PDFWe classify all regular solutions of the Yang-Baxter equation of eight-vertex type. Regular solutions correspond to spin chains with nearest-neighbor interactions. We find a total of four independent solutions.
View Article and Find Full Text PDFRadiation-induced damage to the bone, soft tissues, and vasculature represents the unfortunate consequences of radiation therapy for the treatment of malignant tumors. Complications arising from irradiation are frequently challenging to manage and may be life threatening. A case is presented of a patient with a longstanding clavicular osteoradionecrosis with an acute massive hemorrhage after rupture of the subclavian artery and subsequent management with endovascular stent placement.
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