Publications by authors named "C E Oswalt"
We describe the case of a 27-year-old male, previously healthy though with a social history notable for recreational cocaine use, who developed bone marrow failure due to aplastic anemia (AA) with associated serous fat atrophy (SFA). After the SFA was corrected with nutritional supplementation, the patient underwent successful allogeneic, haploidentical stem cell transplantation with a regimen designed to treat AA. To our knowledge, this is the first case of hematopoietic stem cell transplantation (HSCT) performed following correction of SFA.
View Article and Find Full Text PDFContext: Early specialist palliative care (PC) involvement in metastatic non-small cell lung cancer (mNSCLC) is associated with improved quality of life, less aggressive end of life (EoL) care, and longer survival. As treatment paradigms for NSCLC have evolved, PC utilization remains low.
Objectives: This work examines how the timing and extent of PC involvement impacts outcomes and the patient experience in mNSCLC in the era of immunotherapy.
Citrus Huanglongbing (HLB) caused by ' Liberibacter asiaticus' (CLas) is the most devastating citrus disease worldwide. CLas induces systemic and chronic reactive oxygen species (ROS) production, which has been suggested to be a primary cause of cell death in phloem tissues and subsequent HLB symptoms. Mitigating oxidative stress caused by CLas using horticultural approaches has been suggested as a useful strategy to reduce HLB damages.
View Article and Find Full Text PDFArticle Synopsis
- Chemotherapy is effective for treating cancer, but chemotherapy-induced neutropenia (CIN) and febrile neutropenia (FN) limit treatment effectiveness by causing delays in receiving full doses of medication.
- New biosimilars and therapies, like long-acting G-CSF products and innovative agents, are emerging, helping to improve access, reduce costs, and maintain efficacy in the treatment of CIN.
- Ongoing clinical trials are investigating these new agents to potentially enhance patient outcomes and decrease disparities in access to effective cancer treatments.
Associations between body mass index, weight loss and overall survival in patients with advanced lung cancer.
J Cachexia Sarcopenia Muscle
December 2022
Background: Weight loss (WL) has been associated with shorter survival in patients with advanced cancer, while obesity has been associated with longer survival. Integrating body mass index (BMI) and WL provides a powerful prognostic tool but has not been well-studied in lung cancer patients, particularly in the setting of clinical trials.
Methods: We analysed patient data (n = 10 128) from 63 National Cancer Institute sponsored advanced non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) trials.