Publications by authors named "C E McKinney"
Background: Maternal obesity is associated with significant racial disparities. People who identify as non-Hispanic Black and Latinx are at the highest risk related adverse short- and long-term health outcomes (eg, hypertension in pregnancy and postpartum weight retention). Remote lifestyle interventions delivered during and after pregnancy hold promise for supporting healthy weight outcomes; however, few are tested in groups of people who self-identify as non-Hispanic Black and Latinx or address the neighborhood-level and psychosocial factors driving maternal health disparities.
View Article and Find Full Text PDFArticle Synopsis
- HIV-1 infection remains a major global health issue, with around 30 million individuals receiving antiretroviral treatment, where integrase strand-transfer inhibitors (INSTIs) play a key role in effective therapy.
- The research focuses on evaluating the off-target effects of clinically approved INSTIs on recombinase activating genes (RAG1 and RAG2), crucial for the immune system, using various biochemical and cellular tests.
- Results indicate that approved INSTIs have minimal to no adverse effects on RAG activity and V(D)J recombination, supporting their continued use in HIV-1 treatment without significant immune system concerns.
Objective: The purpose of this study was to assess the impact of adoption of a new cardiac chest pain pathway that included hs-cTnI in the emergency department (ED) when evaluating chest pain patients.
Methods: A new pathway incorporating both hs-cTnI testing (Seimens Healthineers Atellica) and risk stratification tools was developed. The impact of the new algorithm was assessed through a retrospective observational review of patients admitted to the ED with chest pain before implementation and after implementation.
Article Synopsis
- The Blood and Marrow Transplant Clinical Trials Network is running a study to help kids ages 5 to almost 15 with sickle cell disease by using special stem cell transplants.
- They started by only allowing kids who had a clear stroke to join, but then they opened it up to others who had silent brain injuries or high-risk blood flow problems.
- They created different stages for kids to qualify based on serious health issues, like breathing problems or ongoing pain, to ensure the best chance for help in the trial.
Hepatitis B virus (HBV) reactivation can occur in immunosuppressed patients. Specifically, HBV reactivation after chimeric antigen receptor T-cell (CAR T-cell) therapy is a known complication with few case reports and specific treatment guidelines. Our patient experienced HBV reactivation 27 months after CAR T-cell therapy even with 23 months of entecavir prophylaxis.
View Article and Find Full Text PDF