Publications by authors named "C E M Voorter"
Article Synopsis
- * Currently, about 20% of the combined haplotypes from Europe are represented, but many common and rare haplotypes, particularly those associated with certain diseases, are still lacking from the global sample.
- * The workshop is now seeking DNA samples from diverse populations, especially non-Europeans, resulting in 537 individuals contributing 294 distinct haplotypes, but still highlighting the need for more representation, particularly from African populations.
Multiple myeloma (MM) is a hematological malignancy caused by the clonal expansion of malignant plasma cells in the bone marrow. Myeloma cells are susceptible to killing by natural killer (NK) cells, but NK cells fail to control disease progression, suggesting immunosuppression. The activation threshold of NK-effector function is regulated by interaction between KIRs and self-HLA class I, during a process called "education" to ensure self-tolerance.
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- Previous methods for identifying HLA alleles were limited, focusing only on the peptide binding groove, leaving gaps in the HLA database that complicated allele assignments.
- Researchers sequenced full-length regions of 19 HLA class I and 7 class II alleles, alongside extending another 47 class I alleles, adding significant new sequence data to the database.
- This expanded genetic information allows for better understanding of evolutionary origins and enhances the accuracy of HLA allele alignment and assignment in future research.
The international high-resolution external proficiency testing (EPT) started in 2004 with high-resolution typing of human leucocyte antigen (HLA) class I (HLA-A,B,C) and HLA class II (HLA-DRB1, DRB345, DQB1, and DPB1) alleles, since possibilities for such an EPT within Europe were limited and all existing EPTs at that time made use of the comparison of HLA typing results without a reference. This EPT was set up as a collaboration between the HLA laboratory of Leiden, providing DNA samples to the participants, and the laboratory of Maastricht, performing the high-resolution typing as the reference result and evaluating the results of all participants according to the prevailing European Federation for Immunogenetics (EFI) standards. Once a year, 12 samples were sent to the participating laboratories, and evaluation and certificates were provided at the end of that same year.
View Article and Find Full Text PDFIn kidney transplantation, survival rates are still partly impaired due to the deleterious effects of donor specific HLA antibodies (DSA). However, not all luminex-defined DSA appear to be clinically relevant. Further analysis of DSA recognizing polymorphic amino acid configurations, called eplets or functional epitopes, might improve the discrimination between clinically relevant vs.
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