Publications by authors named "C E Luyt"
Multisystem inflammatory syndrome in children (MIS-C) is a rare condition following SARS-CoV-2 infection associated with intestinal manifestations. Genetic predisposition, including inborn errors of the OAS-RNAseL pathway, has been reported. We sequenced 154 MIS-C patients and utilized a novel statistical framework of gene burden analysis, "burdenMC," which identified an enrichment for rare predicted-deleterious variants in BTNL8 (OR = 4.
View Article and Find Full Text PDFSimilar Kinetics of Pulmonary SARS-CoV-2 Load in Intensive Care Unit Patients with COVID-19 Pneumonia with or Without Autoantibodies Neutralizing Type I Interferons.
J Clin Immunol
November 2024
Purpose: The pathogenesis of life-threatening coronavirus disease 2019 (COVID-19) pneumonia in ICU patients can involve pre-existing auto-antibodies (auto-Abs) neutralizing type I interferons (IFNs). The impact of these auto-Abs on SARS-CoV-2 clearance in the lower respiratory tract (LRT) is unclear.
Methods: We performed a retrospective study in 99 ICU patients with COVID-19 pneumonia between March and May 2020.
Purpose: Fever is frequent after extracorporeal membrane oxygenation (ECMO) decannulation. We aimed to evaluate the incidence of post-decannulation fever and describe its causes.
Methods: Adult ECMO patients who were successfully weaned from ECMO were retrospectively included.
Objectives: Vascular complications after venoarterial extracorporeal membrane oxygenation (ECMO) remains poorly studied, although they may highly impact patient management after ECMO removal. Our aim was to assess their frequency, predictors, and management.
Design: Retrospective, observational cohort study.
Article Synopsis
- This study examines the effectiveness of switching patients from peripheral veno-arterial ECMO (pECMO) to central ECMO (cECMO) as a treatment strategy for refractory cardiogenic shock (rCS).
- Out of 80 patients analyzed, only 38% were successfully bridged to recovery, heart transplantation, or a ventricle assist device, while the remaining 62% died during cECMO treatment.
- Complications were common, with high rates of renal issues and bleeding, and the study found that myocardial infarction significantly increased the risk of in-hospital mortality.