Publications by authors named "C E Lehner"
Article Synopsis
- The study investigates how pre-pregnancy obesity may increase the risk of preterm birth by examining metabolites, Flt3L levels, and proinflammatory cytokine profiles in pregnant women.
- Researchers analyzed blood samples from 124 women in Australia, finding that mothers who gave birth preterm had lower Flt3L and higher IL-6 levels compared to those who delivered at term.
- The findings indicate that maternal obesity alters metabolite levels and reduces Flt3L expression, which could contribute to the increased risk of preterm births among obese mothers.
Background: Inconsistent findings about the impact of the COVID-19 pandemic on cardiovascular disease diagnosis and consultations have been reported internationally. The objective of this study was to analyse the impact of the pandemic period (2020-2021) on the incidence rate of coronary heart disease (CHD) compared with the pre-pandemic period (2012-2019) in Bavaria, Germany.
Methods: We used health claims data of around 9 million statutorily insured residents (≥20 years) of Bavaria, Germany.
Article Synopsis
- - The RidStress 2 trial is a phase III study investigating whether maternal oral sildenafil citrate during labor can reduce the need for emergency caesarean sections due to fetal distress in women with small for gestational age infants.
- - The trial involves 660 women and aims to determine the effect of sildenafil citrate on cesarean rates, along with assessing cost-effectiveness and long-term child neurodevelopment.
- - Ethics approval has been secured, and results will be shared through scientific presentations and publications, with the trial registered with relevant clinical trial authorities.
Background: Vaccination is essential, especially in older adults whose immune system function declines with age. The COVID-19 pandemic and its associated lockdowns temporarily disrupted routine vaccination services. We aimed to assess vaccination coverage for Influenza, Pneumococcus, and Herpes zoster among older adults in Bavaria over time and investigate potential pandemic effects on these rates.
View Article and Find Full Text PDFNatural killer (NK) cells play a vital role in innate immunity and show great promise in cancer immunotherapy. Traditional sources of NK cells, such as the peripheral blood, are limited by availability and donor variability. In addition, in vitro expansion can lead to functional exhaustion and gene editing challenges.
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