Dynamics of Antibody Binding and Neutralization during Viral Infection.

In vivo in infection, virions are constantly produced and die rapidly. In contrast, most antibody binding assays do not include such features. Motivated by this, we considered virions with n = 100 binding sites in simple mathematical models with and without the production of virions.

Frazil ice changes winter biogeochemical processes in the Lena River.

The ice-covered period of large Arctic rivers is shortening. To what extent will this affect biogeochemical processing of nutrients? Here we reveal, with silicon isotopes (δSi), a key winter pathway for nutrients under river ice. During colder winter phases in the Lena River catchment, conditions are met for frazil ice accumulation, which creates microzones.

Dynamics of antibody binding and neutralization during viral infection.

In vivo in infection, virions are constantly produced and die rapidly. In contrast, most antibody binding assays do not include such features. Motivated by this, we considered virions with n=100 binding sites in simple mathematical models with and without the production of virions.

A pilot randomised controlled trial of acceptance and commitment therapy for medication decision-making and quality of life in women with breast cancer: The ACTION trial.

Objective: Non-adherence to adjuvant endocrine therapy (AET) in women with breast cancer is common and associated with medication side-effects and distress. We co-designed an Acceptance and Commitment Therapy intervention (ACTION) to enhance medication decision-making and quality of life (QoL). We undertook a pilot trial of ACTION to inform the feasibility of a phase III trial, and to examine intervention acceptability.