Publications by authors named "C E Hioe"
Article Synopsis
- The study focuses on the HIV-1 envelope (Env) protein, crucial for developing effective vaccines, and explores how the signal peptide (SP) affects its antigenicity (ability to trigger immune response) and immunogenicity (ability to induce an immune response).
- Researchers compared the Env proteins from two different HIV-1 isolates, assessing their natural forms and chimeras with swapped SPs, using various methods to evaluate their antigenicity and responses in mice.
- Results showed that swapping SPs influenced the antibodies' binding, with some chimeras showing improved immunogenicity, while the inclusion of DNA vaccines reduced the effectiveness of the wild-type proteins in generating a strong immune response.
Bacteria dysbiosis and its accompanying inflammation or compromised mucosal integrity is associated with an increased risk of HIV-1 transmission. However, HIV-1 may also bind bacteria or bacterial products to impact infectivity and transmissibility. This study evaluated HIV-1 interactions with bacteria through glycan-binding lectins.
View Article and Find Full Text PDFIntroduction: Antibodies against the SARS-CoV-2 spike protein are a critical immune determinant for protection against the virus. While virus neutralization is a key function of spike-specific antibodies, antibodies also mediate Fc-dependent activities that can play a role in protection or pathogenesis.
Methods: This study characterized serum antibody responses elicited after two doses of heterologous adenovirus-vectored (Ad26/ Ad5) vaccines.
Introduction: Neutralizing antibodies (Abs) are one of the immune components required to protect against viral infections. However, developing vaccines capable of eliciting neutralizing Abs effective against a broad array of HIV-1 isolates has been an arduous challenge.
Objective: This study sought to test vaccines aimed to induce Abs against neutralizing epitopes at the V1V2 apex of HIV-1 envelope (Env).