Publications by authors named "C E Hartford"
: Patients in cardiogenic shock (CS) may be successfully bridged using intravascular micro-axial left ventricular assist devices (M-LVADs) for recovery or determination of definitive therapy. : One hundred and seven CS patients implanted with M-LVADs from January 2020 to May 2024 were divided into four groups; group-1: 34 patients (transplant); group-2: 25 patients (LVAD); group-3: 42 patients (postcardiotomy CS (PCCS)); group-4: 6 patients (decision/recovery but excluded from analysis). Multivariable logistic regression and Multivariable Coxregression models identified predictors of early -hospital and late mortality, and Odds ratios (ORs) and hazard ratios (HRs) with < 0.
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- - Transcription factors, like Forkhead box A1 (FOXA1), are crucial for gene regulation in development and disease; FOXA1 is particularly important in cancer, acting as a pioneer factor and an oncogene while being reduced in colorectal cancer (CRC), suggesting it may have tumor-suppressing roles.
- - Research revealed that in CRC, FOXA1 mRNA is unstable, primarily due to its 3'UTR, and this instability is consistent across various CRC cell lines and patient organoids.
- - Staufen1 (STAU1) was identified as a key regulator of FOXA1; knocking down STAU1 led to increased FOXA1 mRNA stability and expression, highlighting a complex mechanism
Introduction: Generalized myasthenia gravis (gMG) is a rare autoimmune disease. Symptoms of gMG are diverse, and understanding of their impact on patients is limited. This qualitative study aimed to provide an in-depth exploration of patients' daily experiences of gMG.
View Article and Find Full Text PDFIntroduction: Following a review of patient-reported outcome (PRO) instruments in the literature, existing PRO instruments may not adequately capture the experience of receiving treatment for proliferative diabetic retinopathy (PDR). Therefore, this study aimed to develop a de novo instrument to comprehensively assess the patient experience of PDR.
Methods: This qualitative, mixed-methods study comprised item generation for the Diabetic Retinopathy-Patient Experience Questionnaire (DR-PEQ), content validation in patients with PDR, and preliminary Rasch measurement theory (RMT) analyses.