Publications by authors named "C E Hack"
[Importance of parametric and molecular imaging for therapeutic management of breast cancer].
Radiologie (Heidelb)
December 2024
Background: In recent years, various magnetic resonance (MRI) and positron emission tomography (PET) parameters have been investigated in breast cancer. Parametric imaging focuses on the visualization and quantification of biological, physiological, and pathological processes at the cellular and molecular level. It therefore provides important insights into the key processes in carcinogenesis and tumor progression.
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- The study investigates the role of CCND1 gene amplification in the prognosis of hormone receptor-positive breast cancer patients, particularly in the context of resistance to endocrine therapy.
- A cohort of 894 breast cancer patients was analyzed, revealing that 12.9% had CCND1 amplification, predominantly in luminal B-like and HER2-positive tumor types.
- The findings indicate that while CCND1 amplification is common in certain breast cancer subtypes, it does not show significant differences in disease-free survival or overall survival among HR-positive, HER2-negative patients.
Background: Assessment of breast volume has a relevance for aesthetic surgery and for the prevention and prediction of breast diseases. This study investigated breast volume measurements using a three-dimensional (3D) body surface scanner integrated in a smartphone device in comparison with magnetic resonance imaging (MRI) scans.
Methods: Breast volume was assessed for 22 women who underwent routine MRI imaging.
Background And Purpose: Complement factor C2 is a potential therapeutic target in immune-mediated neuropathies. However, literature suggests that classical complement pathway activation may proceed to C3 in the absence of C2, a so-called "C2 bypass." Here, we evaluated a C2 bypass mechanism during complement activation by pathogenic human IgM from patients with immune-mediated neuropathies.
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- Physical training is known to lower cancer risk, and it’s suggested that myokines released by skeletal muscle have an anti-tumor effect, but more research is needed, particularly in breast cancer patients.
- A study involving 12 weeks of resistance training with whole-body electromyostimulation (WB-EMS) showed improvements in physical performance and muscle mass in breast cancer patients, along with their blood serum inhibiting cancer cell growth in lab tests.
- The research highlights that myokines, like CXCL1, IL10, and CCL4, can enhance the death of cancer cells, indicating the potential for physical exercise to be a supportive therapy in breast