Publications by authors named "C E Gruber"
Article Synopsis
- Inborn errors of immunity (IEIs) are genetic disorders that increase the risk of infections, autoimmunity, and other health issues, and often show incomplete penetrance despite being caused by single gene mutations.
- This study examines how autosomal random monoallelic expression (aRMAE)—where only one allele of a gene is actively expressed—contributes to the variability in disease outcomes among individuals within families with IEIs.
- The findings reveal that specific gene expression patterns related to aRMAE can influence clinical phenotypes, suggesting that understanding both genetic and expression variations is crucial for analyzing the impact of monogenic disorders.
Electrocatalytic nitrate reduction (NORR) is a promising method for pollutant removal and ammonia synthesis and involves the transfer of eight electrons and nine protons. As such, the rational design of catalytic interfaces with enhanced mass transfer is crucial for achieving high ammonia yield rates and Faradaic efficiency (FE). In this work, we incorporated a Cu-bipyridine catalytic interface and fabricated crystalline 2D covalent organic framework films with significantly exposed catalytic sites, leading to improved FE and ammonia yield (FE=92.
View Article and Find Full Text PDFCurrently, there is a growing preference for eco-friendly bioinsecticides over chemical insecticides due to their safety. Plant extracts have emerged as a promising solution for this purpose. Therefore, this study aimed to evaluate the insecticidal effectiveness of extract against two key pests of rose aphid () and pistachio psylla ().
View Article and Find Full Text PDFArticle Synopsis
- T follicular helper (Tfh) cells, which are important for antibody production, rely heavily on the immunoreceptor PD-1, and its deficiency leads to weakened Tfh functions and impaired immune responses in mice.
- Individuals lacking PD-1 or PD-L1 demonstrate fewer memory B cells and diminished antibody responses, highlighting the critical role of these molecules in immune system functionality.
- PD-1 influences both the intrinsic and extrinsic aspects of B cell memory and antibody production, suggesting that disruptions in PD-1 signaling can lead to complications in immune responses, especially during anti-PD-1-PD-L1 therapies.
Article Synopsis
- - The new pump-probe system uses a 60-MHz dual-comb oscillator and ultra-low noise supercontinuum to improve measurement speed and reduce complexity, especially for low excitation fluences.
- - This setup is capable of operating in different modes and allows for detailed study of excited-state dynamics, specifically of the non-fullerene electron acceptor Y6, which is important for solar cell technology.
- - The system achieves high sensitivity in differential transmission measurements and aims to enhance ultrafast spectroscopy research.