Publications by authors named "C E Grattan"
Article Synopsis
- * Current treatment guidelines suggest increasing doses of second-generation antihistamines, but many patients don't see improvement due to various underlying causes.
- * New research is shifting toward personalized treatments based on individual patient factors, with promising developments like targeted therapies and medications that may effectively modify the disease.
Article Synopsis
- A significant percentage (31.2%) of patients with chronic spontaneous urticaria (CSU) experience non-skin-related symptoms (NSRS) like recurrent fever, joint/bone/muscle pain, and malaise.
- These NSRS are linked to various trigger factors such as food and infections, as well as clinical characteristics like sleep disturbances and elevated inflammation markers.
- Patients with NSRS tend to have worse disease activity, longer duration of CSU, lower quality of life, and a higher likelihood of poor control over their symptoms, highlighting the need for improved management strategies.
Article Synopsis
- There is a significant lack of clear guidance on how and when to reduce treatment for chronic spontaneous urticaria (CSU) despite advances in therapies.
- The SDown-CSU study, which involved 103 physicians across 34 countries, found that many national management guidelines do not address the specifics of discontinuing CSU treatments, especially for medications like antihistamines and cyclosporine.
- The study emphasizes the need for clear protocols and provides a step-down algorithm to help manage CSU treatment more effectively at various stages.