Publications by authors named "C E Elling"
Article Synopsis
- Obstructive sleep-disordered breathing (oSDB) is becoming more common worldwide, especially in children, and it can lead to various health issues that impact quality of life.
- Researchers studied the tonsils of children with oSDB to identify specific genes that may serve as biomarkers, focusing on the presence of Epstein-Barr virus (EBV) and the use of CPAP treatment.
- Nineteen specific genes were found to be dysregulated in the tonsils, suggesting they could help assess the severity and related health problems of oSDB, and that their levels may be influenced by EBV infection.
Background And Purpose: The cannabinoid CB receptor has a well-established role in appetite regulation. Drugs antagonizing central CB receptors, most notably rimonabant, induced weight loss and improved the metabolic profile in obese individuals but were discontinued due to psychiatric side effects. However, metabolic benefits were only partially attributable to weight loss, implying a role for peripheral receptors, and peripherally restricted CB receptor antagonists have since been of interest.
View Article and Find Full Text PDFThe A2ml1-Knockout mouse as an animal model for non-syndromic otitis media.
Int J Pediatr Otorhinolaryngol
June 2024
Background: Inflammation and infection of the middle ear, known as otitis media (OM), is a leading cause of hearing loss and the most frequently diagnosed disease in children worldwide. Traditionally, mouse models for OM rely on inducing acute infection through inoculation of the middle ear, e.g.
View Article and Find Full Text PDFOtitis media (OM) is defined as middle ear (ME) inflammation that is usually due to infection. Globally, OM is a leading cause of hearing loss and is the most frequently diagnosed disease in young children. For OM, pediatric patients with Down syndrome (DS) demonstrate higher incidence rates, greater severity, and poorer outcomes.
View Article and Find Full Text PDFBackground: Up to now several subtypes of social anxiety disorder (SAD) have been proposed.
Methods: In the present study, we used a cluster analytic approach to identify qualitatively different subgroups of SAD based on temperament characteristics, that is, harm avoidance (HA) and novelty seeking (NS) dimensions of Cloninger's Temperament and Character Inventory.
Results: Based on a large, diverse clinical sample (n = 575), we found evidence for two distinct subgroups of SAD: a larger (59%) prototypic, inhibited cluster characterized by high HA and low NS, and a smaller atypic, and comparatively more impulsive cluster characterized by medium to high HA and increased NS.