Acute-on-chronic liver failure (ACLF): the 'Kyoto Consensus'-steps from Asia.

Acute-on-chronic liver failure (ACLF) is a condition associated with high mortality in the absence of liver transplantation. There have been various definitions proposed worldwide. The first consensus report of the working party of the Asian Pacific Association for the Study of the Liver (APASL) set in 2004 on ACLF was published in 2009, and the "APASL ACLF Research Consortium (AARC)" was formed in 2012.

Metabolic landscape and rewiring in normal hematopoiesis, leukemia and aging.

Recent advancements in metabolism research have demonstrated its critical roles in a lot of critical biological processes, including stemness maintenance, cell differentiation, proliferation, and function. Hematopoiesis is the fundamental cell differentiation process with the production of millions of red blood cells per second in carrying oxygen and white blood cells in fighting infection and cancers. The differentiation processes of hematopoietic stem and progenitor cells (HSPCs) are accompanied by significant metabolic reprogramming.

A protocol to assess the Knee cartilage thickness in healthy older adults and analyze its correlation with patient-reported outcomes.

Knee osteoarthritis (KOA)is a degenerative joint condition affecting about 240 million people worldwide with rising incidences in India. The progressive nature of the disease leads to pain, reduced mobility, and diminished quality of life. Despite extensive global research, there is a lack of normative data on the cartilage thickness specific to the Indian population, which is crucial to understanding the nature of the disease progression.

Urinary leptospiral sphingomyelinases as diagnostic markers of leptospirosis in dengue patients co-infected with leptospirosis.

The study aims to evaluate the diagnostic potential of pathogen-specific leptospiral sphingomyelinases, LipL32, LipL41, and HbpA in human patients with dengue-leptospirosis coinfection. Patients (n-86), upon clinical evaluation, were categorized into Group I (n-37; leptospirosis), Group II (n-39; dengue-leptospirosis coinfection), and Group III (n-10; negative for both dengue and leptospirosis). ELISA identified significant levels of the four leptospiral antigens in the urine of Group I and II, but not in Group III patients.