Publications by authors named "C E Dempsey"
Objective: This study investigated methods of evaluating the bone fracture healing process using superb microvascular imaging (SMI; two modes color SMI [cSMI] and monochromeSMI [mSMI]), and shear wave elastography (SWE), relative to X-ray, dual-energy X-ray absorptiometry (DXA), and platelet endothelial cell adhesion molecule 1 (PECAM-1) also know as cluster of differentiation 31 (CD-31) staining in a rabbit model.
Methods: This IACUC-approved study involved eight rabbits that underwent a bilateral fibula osteotomy and were followed for 7 or 21 days (Groups 1 and 2 with 4 rabbits in each). Ultrasound examinations using cSMI, mSMI, and SWE were performed on Days 0, 4, 7, 14, and 21 post-surgery.
Article Synopsis
- Potassium channels from the human hERG gene are affected by various drugs, and this study specifically investigates the effects of chiral disopyramide, a Class Ia antiarrhythmic, on hERG currents in HEK 293 cells.* -
- The findings show that the S(+) enantiomer of disopyramide is more potent at inhibiting hERG current compared to the R(-) form, with IC values of 3.9 µM and 12.9 µM respectively, and certain mutations in hERG alter these effects.* -
- Molecular simulations indicate that the S(+) form binds more effectively to specific residues in the hERG channel, while the R(-)
Article Synopsis
- The study investigates Alzheimer's disease-related psychosis (ADP) in older adults, focusing on demographic and clinical differences between those treated with antipsychotics and those who are not.
- Researchers analyzed data from over 145,000 ADP patients, comparing health outcomes related to falls, fractures, seizures, and mortality between the two groups.
- Findings reveal that antipsychotic users had more baseline health issues and higher rates of falls, fractures, and mortality compared to nonusers, indicating a significant impact of antipsychotic treatment on health outcomes in ADP patients.