Publications by authors named "C E Costentin"
Background & Aims: The accuracy of non-invasive tests (NITs) should be ≥80% (EASL recommendation). We aimed to compare the accuracies of the recommended NITs for advanced fibrosis in MASLD and improve NIT accuracy.
Methods: 1051 MASLD patients were allocated to derivation (n=637) and validation (n=414) sets.
Article Synopsis
- Metalloenzymes, particularly hydrogenases, utilize pendant bases at their active sites to facilitate proton relay for effective proton-coupled electron-transfer during hydrogen evolution and oxidation reactions.
- Various biomimetic and bioinspired molecular systems that include these proton relays are reviewed, emphasizing their design and functionality in catalysis.
- The discussion includes essential parameters for achieving bidirectional and reversible catalysis, along with examples from existing literature that illustrate these catalytic processes.
Article Synopsis
- An electrocatalyst can create localized microenvironments with unique pH properties that impact proton-coupled electron transfer reactions, affecting energy efficiency and selectivity.
- While local pH effects have been studied in reductive reactions like CO reduction, understanding these effects in oxidative reactions, particularly the oxygen evolution reaction (OER), has been challenging due to limitations of traditional techniques.
- A new model developed accounts for local pH changes based on current density, showing that acid-stable catalysts, like PbO, can experience pH gradients during OER, highlighting the need for stable OER catalysts in basic conditions.
Explant-based models for assessing HCC recurrence after liver transplantation serve as the gold standard, guiding post-liver transplantation screening and immunosuppression adjustment. Incorporating alpha-fetoprotein (AFP) levels into these models, such as the novel R3-AFP score, has notably enhanced risk stratification. However, validation of these models in high-evidence data is mandatory.
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- Liver fibrosis often goes unnoticed but is a key factor in liver-related deaths; this study introduces a systematic method for screening it using the FIB-4 score.
- A centralized approach at a French University Hospital involved calculating FIB-4 for nearly 3,000 patients and identified 135 at risk for advanced fibrosis, leading to further testing in a subset of those patients.
- The study found significant fibrosis in 15 patients through follow-up consultations, highlighting the need to increase awareness and improve referral processes for better patient care.