Publications by authors named "C E Costello"
What Is This Summary About?: This summary describes the final analysis of the GRIFFIN study. In this study, participants were newly diagnosed with a type of blood and bone marrow cancer called multiple myeloma, had never received any treatment, and were able to undergo an autologous stem cell transplant. The GRIFFIN study looked at adding the drug daratumumab (D) to a combination of standard treatments called RVd (lenalidomide [R], bortezomib [V], and dexamethasone [d]) during the treatment phases induction and consolidation, followed by daratumumab and lenalidomide (D-R) maintenance.
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- - The study highlights the importance of user input in creating digital health interventions (DHIs) to improve their acceptance for secondary prevention of cardiovascular disease (CVD).
- - A co-design approach was employed in developing the INTERCEPT DHI, involving health professionals and users in a four-phase process to ensure the app meets real needs and is user-friendly.
- - Key design principles such as simplicity, personalization, and social support were identified, leading to significant improvements in usability scores after testing and implementing user feedback.
Background: Combination immune checkpoint blockade targeting PD-1 and CTLA-4 leads to high response rates and improved survival in advanced cutaneous melanoma (CM). Less is known about the efficacy of this combination in acral lentiginous melanoma (ALM).
Objectives: To determine the efficacy of combination immune checkpoint blockade targeting PD-1 and CTLA-4 in a real-world, diverse population of ALM.