Publications by authors named "C E Conrath"
Article Synopsis
- Successful recanalization of chronic total occlusions (CTOs) in patients is linked to better clinical outcomes, possibly due to reduced arrhythmias from changes in the heart muscle (myocardium) in affected areas.
- A systematic review and meta-analysis of eight studies with 467 patients were conducted, revealing significant decreases in specific ECG parameters (QT dispersion, QTc dispersion, and Tp-e intervals) after successful CTO percutaneous coronary intervention (PCI).
- The findings suggest that successful CTO PCI improves heart electrical activity, potentially lowering the risk of dangerous heart rhythms and sudden cardiac death, challenging the notion that the affected heart muscle is entirely inactive.
Mechano-electric coupling, heterogeneity in repolarization and the electrocardiographic T-wave.
Prog Biophys Mol Biol
November 2017
Stretch influences repolarization by mechano-electric coupling (MEC) and contributes to arrhythmogenesis. Although there is an abundance of research on electrophysiological effects of MEC, it is still unclear how MEC translates to the ECG. We aim to provide an overview of the MEC research focused on the ECG and the underlying changes in electrophysiology.
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- J-waves in the inferolateral leads increase the risk of idiopathic ventricular fibrillation, and this study investigates mechanisms behind their occurrence.
- The research utilized computer simulations and pig heart experiments to explore how changes in sodium and potassium currents can affect J-point elevations in these leads.
- Findings suggest that decreased sodium current in the left lateral ventricle leads to inferolateral J-waves, particularly due to delayed myocardial activation.
Background: Brugada syndrome (BrS) is characterized by a typical ECG pattern. We aimed to determine the pathophysiologic basis of the ST-segment in the BrS-ECG with data from various epicardial and endocardial right ventricular activation mapping procedures in 6 BrS patients and in 5 non-BrS controls.
Methods And Results: In 7 patients (2 BrS and 5 controls) with atrial fibrillation, an epicardial 8×6 electrode grid (interelectrode distance 1 mm) was placed epicardially on the right ventricular outflow tract (RVOT) before video-assisted thoracoscopic surgical pulmonary vein isolation.
Aims: Pulmonary vein isolation (PVI) aims at eliminating symptomatic atrial fibrillation. In this regard, the most relevant indication for this procedure is the reduction of symptoms and improvement of quality of life (QoL) in patients who remain symptomatic despite antiarrhythmic drug treatment. We investigated the relation between documented atrial fibrillation recurrences and QoL in patients after PVI.
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