Publications by authors named "C E Cicero"
Article Synopsis
- The study investigates two phenotypes of Parkinson's Disease (PD) based on the timing of REM sleep behavior disorder (RBD) onset in relation to motor symptoms: "body first" (RBD before motor symptoms) and "brain first" (RBD after motor symptoms).
- Researchers analyzed striatal dopaminergic function in PD patients using imaging and found that the "body first" group exhibited more symmetrical motor impairment, higher cognitive decline, and distinctive imaging results compared to those with later onset RBD.
- The findings corroborate the SOC model's predictions, indicating different patterns of neurological function and cognitive impairment linked to the onset of RBD in PD.
Background: L-dopa (LD) effects on visually guided saccades (VGS) have been poorly investigated in de novo Parkinson's disease (PD) patients through a standardized acute challenge test.
Objectives: To assess the acute saccadic effects of LD as well as possible different patterns of VGS response to LD in a consistent population of de novo PD.
Methods: VGS were assessed among de novo PD at baseline and 2 h after the administration of LD/carbidopa 250/25 mg.
Article Synopsis
- Late onset multiple sclerosis (LOMS) accounts for 0.6 to 12% of all MS cases, but there's limited information on its incidence in the general population.
- A study in Catania, Italy, identified 183 LOMS patients (with a mean age of onset at 55.8 years), revealing an average annual incidence rate of 2.87 per 100,000 person-years.
- Over time, the incidence rate increased notably, particularly among individuals aged 60-69, suggesting that MS may begin at older ages.
Article Synopsis
- * The research involved 230 patients, analyzing their EEG recordings to determine a power law exponent (β) that reflects brain connectivity and activity patterns.
- * Results showed that tauopathies had lower β values compared to α-synucleinopathies, suggesting that β could serve as a potential biomarker for distinguishing between these two types of neurodegenerative diseases.
: Kawasaki disease (KD) is a systemic vasculitis of medium arteries, particularly involving coronary arteries. Coronary artery lesions (CALs) is the most serious complication in the acute stage, potentially leading to ischemic cardiomyopathy, myocardial infarction and sudden death. Environmental factors and genetic background contribute to individual susceptibility to develop CALs.
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