Publications by authors named "C E Beekman"
Article Synopsis
- Pharmaceutical manufacturers are creating methods to reduce nitrosamine impurities in drugs, specifically focusing on NDMA, NDEA, NDIPA, and NEIPA.
- A headspace GC-MS method was developed and validated per ICH Q2(R1) guidelines, and modifications were made to test for DMF due to its connection to NDMA formation.
- The validated method showed NDMA levels in "sartan" drugs ranging from 0.1 to 113 ppm and was also utilized to explore ways to lessen nitrosamine impurities in metformin drugs.
Antibiotics cause collateral damage to resident microbes that is associated with various health risks. To date, studies have largely focused on the impacts of antibiotics on large intestinal and fecal microbiota. Here, we employ a gastrointestinal (GI) tract-wide integrated multiomic approach to show that amoxicillin (AMX) treatment reduces bacterial abundance, bile salt hydrolase activity, and unconjugated bile acids in the small intestine (SI).
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- - The study aimed to detect and measure mutant huntingtin (mHTT) levels in tear fluid from individuals with Huntington's disease (HD), a genetic neurodegenerative disorder.
- - Researchers recruited 53 participants (20 manifest HD patients, 13 premanifest carriers, and 20 controls) and found significantly higher levels of mHTT in tears from HD patients compared to controls, with established cutoff values for diagnosis.
- - The findings suggest that measuring mHTT in tear fluid could serve as an early, noninvasive method for diagnosing HD and monitoring disease progression, making it useful for clinical trials and routine diagnostics.
Recent studies have highlighted the influence of factors such as sex and sex-linked hormones on microbiome composition, raising concerns about the generalizability of findings. Here, we explore whether gut geography, specifically the upper and lower gastrointestinal tract (GI), contributes to sex-linked microbiome differences in mice. We collected microbial samples throughout the length of the GI from male and female C57B6/J mice at 6- and 8-weeks old, and conducted 16S rRNA sequencing.
View Article and Find Full Text PDFPurpose: Transarterial radioembolization (TARE) procedures treat liver tumors by injecting radioactive microspheres into the hepatic artery. Currently, there is a critical need to optimize TARE towards a personalized dosimetry approach. To this aim, we present a novel microsphere dosimetry (MIDOS) stochastic model to estimate the activity delivered to the tumor(s), normal liver, and lung.
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