Publications by authors named "C E Aubin"
Study Design: Single-center, double-blinded, prospective crossover randomized controlled trial.
Objective: To clinically validate the efficacy of nighttime braces designed automatically by a generative design algorithm to treat idiopathic scoliosis (IS). The tested hypothesis was the clinical equivalence of immediate in-brace correction for the new automatically generated brace design versus a standard Providence-type brace.
Congenital scoliosis (CS) is a type of vertebral malformation for which the etiology remains elusive. The notochord is pivotal for vertebrae development, but its role in CS is still understudied. Here, we generated a zebrafish knockout of ptk7a, a planar cell polarity (PCP) gene that is essential for convergence and extension (C&E) of the notochord, and detected congenital scoliosis-like vertebral malformations (CVMs).
View Article and Find Full Text PDFFinite element analysis of distraction osteogenesis with a new extramedullary internal distractor.
Comput Methods Biomech Biomed Engin
September 2024
Distraction osteogenesis (DO) is a bone regenerative maneuver, which is conventionally done with external fixators and, more recently, with telescopic intramedullary nails. Despite the proven effectiveness, external approaches are intrusive to the patient's life while intramedullary nailing damages the growth plates, making them unsuitable for pediatric patients. An internal DO plate fixator (IDOPF) was developed for pediatric patients to address these limitations.
View Article and Find Full Text PDFArticle Synopsis
- Oblique lumbar intervertebral fusion is a surgical method to relieve nerve pressure and involves using an interbody fusion cage, but the best surgical approach is still uncertain.
- A biomechanical model was created to evaluate how different patient conditions and implant choices affect spinal alignment, nerve decompression, and the risk of cage sinking into the bone.
- Results showed that using larger cages (14 mm) improved spinal dimensions significantly, while bilateral pedicle screw fixation reduced endplate stress, especially in patients with weak bones.
Article Synopsis
- The study aimed to improve the performance of S2AI screw fixation using a genetic algorithm and patient-specific finite element analysis focusing on bone mechanical properties.
- Patient-specific pelvic finite element models were developed, comparing two optimization methods: one based on bone mass quality (BM method) and the other maximizing screw corridor radius (GEO method), evaluated through pullout and toggle tests.
- Results showed that the BM method achieved significantly higher pullout forces and a more effective screw trajectory compared to the GEO method, indicating a better fixation performance for both normal and osteoporotic bone conditions.