Publications by authors named "C E Almeida"
Growing evidence indicates that type 2 diabetes (T2D) is associated with an increased risk of developing Parkinson's disease (PD) through shared disease mechanisms. Studies show that insulin resistance, which is the driving pathophysiological mechanism of T2D plays a major role in neurodegeneration by impairing neuronal functionality, metabolism and survival. To investigate insulin resistance caused pathological changes in the human midbrain, which could predispose a healthy midbrain to PD development, we exposed iPSC-derived human midbrain organoids from healthy individuals to either high insulin concentration, promoting insulin resistance, or to more physiological insulin concentration restoring insulin signalling function.
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- Antimicrobial resistance (AMR) is a significant global public health issue, prompting this study to examine antibacterial usage and the prevalence of multidrug-resistant organisms (MDRO) in a Brazilian hospital, particularly focusing on the ESKAPE group pathogens.
- The study employed a time series approach, analyzing data from January 2015 to December 2021, revealing increased consumption of specific antibiotics like daptomycin and linezolid, and a noteworthy rise in the incidence of certain MDROs, especially Staphylococcus spp and Enterococcus spp.
- Findings suggest that the COVID-19 pandemic may have worsened the trends of rising AMR, highlighting the need for ongoing surveillance to understand these epidemiological changes better.
Endocrine therapies that comprise anti-estrogens and aromatase inhibitors (AIs) are the standard treatment for estrogen receptor-positive (ER+) (Luminal A) breast cancer-the most prevalent subtype. However, the emergence of resistance restricts their success by causing tumor relapse and re-growth, which demands a switch towards other therapeutic approaches in order to minimize or overcome resistance. Indeed, this clinical limitation highlights the search for new molecules to improve cancer treatment.
View Article and Find Full Text PDFBackground: In recent years, the rise in average lifespan has been linked to an increase in the occurrence of diseases associated with aging worldwide. Rectal tumors often occur in elderly patients.
Methods: Between January and August 2024, 6 experts in colorectal cancer met to develop an algorithm to organize the interdisciplinary and multimodal preoperative approaches in the octogenarian population with rectal cancer.
Objective: to develop a bundle for the safety of psychiatric patients during hospitalization.
Methods: a methodological study conducted in two stages. In the first, a comprehensive literature review was developed through a scoping review and conducted to examine evidence on the safety of psychiatric patients during hospitalization.