Publications by authors named "C E Agnew"
The dosimetric output of a 6FFF beam, produced from a Varian TrueBeam linac exhibited an unexpected downward trend over time that was contrary to well-established expectations. To elucidate the cause of this uncharacteristic trend, a review of the linac's quality control results over its lifetime was performed, including, constancy checks of the dosimetric output, beam energy, flatness and symmetry, and percentage depth dose characteristics. These results were supplemented with a comprehensive series of measurements including flatness and symmetry measurements with a 1D-diode array, high-resolution measurements of the photon beam's build-up region with a parallel-plate chamber and measurement of the beam's output as a function of the x-ray target position.
View Article and Find Full Text PDFβ-Glucocerebrosidase (GBA/GCase) mutations leading to misfolded protein cause Gaucher's disease and are a major genetic risk factor for Parkinson's disease and dementia with Lewy bodies. The identification of small molecule pharmacological chaperones that can stabilize the misfolded protein and increase delivery of degradation-prone mutant GCase to the lysosome is a strategy under active investigation. Here, we describe the first use of fragment-based drug discovery (FBDD) to identify pharmacological chaperones of GCase.
View Article and Find Full Text PDFArticle Synopsis
- The study highlights the growing importance of sports science professionals in teams, noting their reliance on group statistical analyses that may not be suitable for smaller samples or individual athletes.
- It examines four statistical methods (model statistic, smallest worthwhile change, coefficient of variation, and standard error of measurement) for assessing performance improvements at the individual level, providing step-by-step guidance for each.
- The research suggests that using a combination of the model statistic and coefficient of variation will effectively detect meaningful training adaptations in athletes, ensuring the results reflect actual performance changes rather than random fluctuations.
Resurgence refers to the relapse of a target behavior following the worsening of a source of alternative reinforcement that was made available during response elimination. Most laboratory analyses of resurgence have used a combination of extinction and alternative reinforcement to reduce target behavior. In contingency-management treatments for alcohol use disorder, however, alcohol use is not placed on extinction.
View Article and Find Full Text PDFObjective: This study aims to analyse lung tumour motion and to investigate the correlation between the internal tumour motion acquired from four-dimensional computed tomography (4DCT) and the motion of an external surrogate.
Methods: A data set of 363 4DCT images was analysed. Tumours were classified based on their anatomical lobes.