Hormone-containing peptides from normal and goiter human thyroglobulins.

A series of low iodine human thyroglobulin samples derived from colloid-rich goiter tissue was examined by HPLC mapping of tryptic digests and compared to normal human thyroglobulin. These samples ranged in iodine content from 2 to 8 gram-atoms of iodine (g.a.

A comparison of 30-kDa and 10-kDa hormone-containing fragments of bovine thyroglobulin.

Studies have been carried out on reduced and alkylated 19 S bovine thyroglobulin to characterize naturally occurring, iodine-rich fragments. In this report, the purification and properties of a 30-kDa, hormone-enriched polypeptide (TgE) are described and compared to that of a previously reported 10-kDa fragment (TgF). The amino acid sequence of TgF was found to overlap with that of TgE.