Publications by authors named "C Dyck"
Rapid advancements in nanotechnology have allowed for the characterization of single molecules by placing them in the vicinity of nanoplasmonic structures that are known to confine light to sub-molecular scales. In this study, we introduce a theoretical framework that captures higher-order effects, and we explore the limits of the standard description of a molecular emitter as a point-dipole. We particularly focus on the role played by the emitter chain length and electron conjugation.
View Article and Find Full Text PDFWe report a combined experimental (C-AFM and SThM) and theoretical (DFT) study of the thermoelectric properties of molecular junctions made of self-assembled monolayers on Au of thiolated benzothieno-benzothiophene (BTBT) and alkylated BTBT derivatives (C8-BTBT-C8). We measure the thermal conductance per molecule at 15 and 8.8 pW/K, respectively, among the lowest values for molecular junctions so far reported (10-50 pW/K).
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the relationship between metabotropic glutamate receptor subtype 5 (mGluR5) and synaptic density in early Alzheimer's disease (AD) using PET imaging techniques.
- Findings reveal a strong positive correlation between mGluR5 levels and synaptic density in the hippocampus and entorhinal cortex of Alzheimer’s patients, but less significant in cognitively normal individuals.
- The research concludes that loss of mGluR5 in the medial temporal lobe is linked to synaptic loss, suggesting its potential role in AD pathology.
Background: Advances in plasma biomarkers to detect Alzheimer's disease (AD) biology allows researchers to improve the efficiency of participant recruitment into preclinical trials. Recently, protein levels of plasma amyloid-beta and tau proteins have been shown to be predictive of elevated amyloid in brain. Online registries, such as the Alzheimer's Prevention Trials (APT) Webstudy, include and follow participants using remote assessments to facilitate efficient screening and enrollment of large numbers of individuals who may be at higher risk for AD.
View Article and Find Full Text PDFIntroduction: Hearing loss is identified as one of the largest modifiable risk factors for cognitive impairment and dementia. Studies evaluating this relationship have yielded mixed results.
Methods: We investigated the longitudinal relationship between self-reported hearing loss and cognitive/functional performance in 695 cognitively normal (CN) and 941 participants with mild cognitive impairment (MCI) enrolled in the Alzheimer's Disease Neuroimaging Initiative.