[Bone health in Geneva retirees].

GERICO (Geneva Retirees Cohort) is a cohort of 953 men and women recruited at the age of 65 in Canton of Geneva, Switzerland, providing a picture of bone health at retirement time. Despite few comorbidities and good nutritional intake and vitamin D status, 30% of subjects have a history of vertebral or clinical fracture after the age of 45, 20% of women and 11% of men have osteoporosis assessed by DXA. 22% have a 10-year probability of a major osteoporotic fracture assessed by FRAX greater than 15%, -i.

Additive Genetic Effects on Circulating Periostin Contribute to the Heritability of Bone Microstructure.

Context: Genetic factors account for 60-80% of the areal bone mineral density (aBMD) variance, whereas the heritability of bone microstructure is not clearly established. aBMD and microstructure are under the control of osteocytes, which regulate bone formation through the expression of molecules such as sclerostin (SOST) and periostin (POSTN).

Objective: We hypothesized that additive genetic effects contribute to serum levels of SOST and POSTN and thereby to the individual variance of bone microstructure.

Prior ankle fractures in postmenopausal women are associated with low areal bone mineral density and bone microstructure alterations.

Unlabelled: In a cross-sectional analysis in postmenopausal women, prior ankle fractures were associated with lower areal bone mineral density (BMD) and trabecular bone alterations compared to no fracture history. Compared to women with forearm fractures, microstructure alterations were of lower magnitude. These data suggest that ankle fractures are another manifestation of bone fragility.

Microstructural alterations of trabecular and cortical bone in long-term HIV-infected elderly men on successful antiretroviral therapy.

Objective: Progress in antiretroviral therapy (ART) has resulted in an almost normal life expectancy for HIV-infected individuals, but an increased risk of fragility fractures has been identified. We investigated the influence of long-term HIV infection on successful ART on bone microstructure in elderly men.

Design: A cross-sectional, case–control study.

Association of circulating sclerostin with bone mineral mass, microstructure, and turnover biochemical markers in healthy elderly men and women.

Context: Sclerostin inhibits bone formation and is involved in the bone response to mechanical loading, but the role and significance of circulating sclerostin are poorly understood.

Objective: We assessed the association between serum sclerostin and calcitropic hormones, bone turnover marker levels, bone mineral content/density, and microstructure using 3 different immunoassays.

Design, Setting, And Participants: In a cross-sectional study, serum sclerostin was measured in a cohort of 187 healthy subjects (98 women; 89 men) aged 65 ± 1 (±SD) years.