Nuclide++: A C++ module to include DDEP recommended radioactive decay Data in Geant4.

This article describes the Nuclide++ module developed at LNE-LNHB to simulate the decay schemes related to single or multiple radionuclides, by randomly selecting decay pathways. Written in C++, with respect of the Geant4 coding style, this module can be used transparently in Geant4-based simulation applications as an alternative to the existing Radioactive Decay Module (RDM). Nuclide++ takes advantage of the DDEP recommended data, accurate β-emitting spectra calculation and detailed description of the atomic rearrangement.

[Therapeutic antibodies: importance of galenics for efficacy and safety].

Monoclonal antibodies and their derivatives such as antibody fragments, immunoconjugates and Fc fusions, represent the majority of therapeutic proteins in clinical development. Recent successes of such molecules in cancer and in the treatment of autoimmune diseases found a great hope in biotherapeutics. The progress in genetic engineering and in analytical development allowed the production of increasingly humanized antibodies, and thus less immunogenic.

Detailed calculation of K- and L-Auger electron emission intensities following radioactive disintegration.

A program has been set up to calculate the K- and L-Auger electron emissions resulting from the radioactive disintegration process, and to study all the possible emissions in detail. Due to the fact that only a small number of experimental results are available in the measurements of K- and L-Auger electrons, the calculated values obtained in this work were compared with the other calculated values available. Good agreement was found between the values.

Influence of lipid nanocapsules composition on their aptness to freeze-drying.

Purpose: To link the aptness to freeze-drying and the stability under storage to the topology of lipid nanocapsules.

Methods: The aptness to freeze-drying and the stability under storage of lipid nanocapsules prepared from different compositions with a lecithin content in the 2-20% range were estimated from the preservation of the physical structure, preventing the leakage of the oily phase. The influence of the outer shell composition and of the physical characteristics (investigated by photon correlation spectroscopy and differential scanning calorimetry) on the physical stability was correlated to the topology of the nanoparticulate carrier.

A website dedicated to ionizing radiation metrology.

In order to disseminate information about decay data and their evaluation, as well as other topics in the field of ionizing radiation, the Bureau National de Métrologie-Laboratoire National Henri Becquerel (BNM-LNHB) has published a website. Most of the web pages are concerned with the international working groups in which the BNM-LNHB takes part. In particular, a library of uranium and plutonium spectra is now available, as well as the results of evaluation of decay data of nuclides of special interest.