A naturalistic study of the use of vigabatrin, lamotrigine and gabapentin in adults with learning disabilities.

Epilepsy is a common condition in people with learning disabilities with many patients continuing to suffer from seizures despite antiepileptic drug (AED) treatment. Although the advent of newer AEDs offers hope for better treatment, there is a need to compare the efficacy of each new AED in adults with both drug-resistant epilepsy and learning disabilities. This retrospective casenote study involves the analysis of the outcome for those adults with learning disabilities treated with either vigabatrin, lamotrigine or gabapentin.

Adaptive behaviour after schizophrenia in people with Down's syndrome.

Seven individuals with Down's syndrome and a past history of schizophrenia were matched for age, sex and residence to adults with Down's syndrome but no past psychiatric history. The AAMD Adaptive Behaviour Scale was completed for all individuals in both groups, at a mean follow-up period of 6.4 years after the schizophrenic episode.