Publications by authors named "C Duane Randleman"
Purpose: To characterize corneal and conjunctival abnormalities (CCAs) and their impact on visual acuity in a cohort of survivors from the Western African Ebola virus disease (EVD) outbreak.
Design: A post hoc analysis of 121 patients, who had previously undergone screening for the Ebola Virus Persistence in Ocular Tissues and Fluids study, was performed.
Methods: Patients underwent a comprehensive ophthalmic exam at the Lowell and Ruth Gess Eye Hospital in Freetown, Sierra Leone.
Purpose: To assess hospitalized COVID-19 inpatients for the prevalence of retinopathy and tear film SARS-CoV-2 RNA, and associated risk factors for their detection.
Methods: Hospitalized COVID-19 patients underwent dilated ophthalmic examination and fundus photography. Conjunctival swabs were assessed for SARS-CoV-2 RT-PCR via a triple target assay.
Article Synopsis
- The study aimed to evaluate how common retinopathy is among patients with severe COVID-19 and its links to overall health and blood-related issues.
- It involved analyzing data from hospitalized adults who underwent eye exams, where retinopathy was identified through specific eye problems such as retinal hemorrhage and cotton wool spots.
- Results showed that 38% of patients had retinopathy, which correlated with more severe systemic health problems, higher inflammation markers, and increased risk factors like male sex and elevated D-dimer levels.
Background: Immunoassays that detect antibovine thrombin product antibodies are not widely available. However, knowing whether these antibodies are present preoperatively would be useful because re-exposure to bovine thrombin-containing products is contraindicated in patients with pre-existing antiproduct antibodies due to the risk of developing immune-mediated coagulopathies. In these exploratory analyses, we characterized one aspect of immune sensitization, the persistence of circulating antibodies after exposure to bovine thrombin product.
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