Publications by authors named "C Drescher"
High-Grade Serous Ovarian Cancer (HGSOC) originates from fallopian tube (FT) precursors. However, the molecular changes that occur as precancerous lesions progress to HGSOC are not well understood. To address this, we integrated high-plex imaging and spatial transcriptomics to analyze human tissue samples at different stages of HGSOC development, including p53 signatures, serous tubal intraepithelial carcinomas (STIC), and invasive HGSOC.
View Article and Find Full Text PDFPurpose: Psychological distress, including anxiety and depression, is common among adults with CF, associating with poor quality of life, lung function, and healthcare utilization. This 3-year, multi-site, telehealth-delivered randomized trial sought to determine whether Acceptance and Commitment Therapy (ACT with CF) is superior to supportive psychotherapy (SP), in improving psychological functioning for adults with CF.
Methods: One hundred twenty-four adults with CF and elevated anxiety and/or depressive symptoms were recruited coincident with the first COVID lockdown, from Thomas Jefferson University Hospitals, University of Virginia, Augusta University, Duke University Medical Center, and social media.
Article Synopsis
- High-Grade Serous Ovarian Cancer (HGSOC) develops from precursors in the fallopian tubes, yet the molecular changes during this progression are poorly understood.
- Researchers used advanced imaging and spatial transcriptomics to analyze tissue samples from different stages of HGSOC, revealing critical immune modulating mechanisms and molecular alterations associated with the disease's progression.
- Findings indicate a shift from immune surveillance to immune suppression in the tumor microenvironment, offering insights into potential biomarkers and therapeutic targets for early detection and intervention in HGSOC.
Introduction: There are disparities in child mental health treatment access and treatment retention in terms of race and ethnicity, socioeconomic status (SES), and insurance coverage. Institutions have invested in the integrated primary care (IPC) treatment model with the goal of improving treatment access and promoting child mental health equity.
Objective: This study compared treatment attendance in an outpatient psychiatry clinic (OPC) versus an IPC clinic to assess whether the IPC was associated with reduced disparities in access to care and treatment retention.
Article Synopsis
- A study in the UK showed that using CA125 blood tests and ultrasound for ovarian cancer didn't really lower deaths but helped find earlier cases.
- Researchers tested blood samples from women with ovarian cancer and controls to create a new test using 7 specific chemicals plus CA125.
- This new test was better at finding early-stage ovarian cancer, catching a good number of cases even when CA125 levels were low.