Publications by authors named "C Drelon"
Background: Ovarian cancer (OC) remains one of the most challenging and deadly malignancies facing women today. While PARP inhibitors (PARPis) have transformed the treatment landscape for women with advanced OC, many patients will relapse and the PARPi-resistant setting is an area of unmet medical need. Traditional immunotherapies targeting PD-1/PD-L1 have failed to show any benefit in OC.
View Article and Find Full Text PDFIn , the larval prothoracic gland integrates nutritional status with developmental signals to regulate growth and maturation through the secretion of the steroid hormone ecdysone. While the nutritional signals and cellular pathways that regulate prothoracic gland function are relatively well studied, the transcriptional regulators that orchestrate the activity of this tissue remain less characterized. Here, we show that lysine demethylase 5 (KDM5) is essential for prothoracic gland function.
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- EZH2 is identified as a key player in the aggressiveness of adrenocortical carcinoma (ACC) by not only repressing certain genes but also promoting the transcription of genes involved in cell cycle regulation.
- Through bioinformatics and experimental techniques, the study revealed that EZH2 works alongside the transcription factor E2F1 to upregulate genes like RRM2, PTTG1, and ASE1/PRC1, which correlate with poor patient outcomes.
- Targeting RRM2 pharmacologically or via siRNA effectively inhibited ACC cell proliferation and migration, suggesting it as a promising therapeutic target in treating aggressive ACC.
Adrenal cortex steroids are essential for body homeostasis, and adrenal insufficiency is a life-threatening condition. Adrenal endocrine activity is maintained through recruitment of subcapsular progenitor cells that follow a unidirectional differentiation path from zona glomerulosa to zona fasciculata (zF). Here, we show that this unidirectionality is ensured by the histone methyltransferase EZH2.
View Article and Find Full Text PDFRegulated gene expression is necessary for developmental and homeostatic processes. The KDM5 family of transcriptional regulators are histone H3 lysine 4 demethylases that can function through both demethylase-dependent and -independent mechanisms. While loss and overexpression of KDM5 proteins are linked to intellectual disability and cancer, respectively, their normal developmental functions remain less characterized.
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