Publications by authors named "C Draghici"

Tetrahydroacridines arouse particular interest due to the potential possibilities of application in the medical field and protection against corrosion. -tetrahydroacridines were newly synthesized by Pfitzinger condensation of 5,5'-(ethane-1,2-diyl) diindoline-2,3-dione with several cyclanones. NMR, MS, and FT-IR were used to prove their molecular structure.

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Article Synopsis
  • * Researchers developed five new sulfanilamide Schiff bases using microwave irradiation, testing them for antimicrobial and antibiofilm activity against various bacteria, as well as their cytotoxicity on cancer cell lines.
  • * The Schiff bases showed better effectiveness than the original sulfanilamide, particularly against Gram-positive bacteria, with specific compounds significantly reducing cancer cell viability, indicating the importance of halogen groups in enhancing their effects.
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Thiadiazole derivatives have garnered significant attention in the field of medicinal chemistry due to their diverse pharmacological activities, including anticancer properties. This article presents the synthesis of a series of thiadiazole derivatives and investigates their chemical characterization and potential anticancer effects on various cell lines. The results of the nuclear magnetic resonance (NMR) analyses confirmed the successful formation of the target compounds.

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In terrestrial plants, strigolactones act as multifunctional endo- and exo-signals. On microalgae, the strigolactones determine akin effects: induce symbiosis formation with fungi and bacteria and enhance photosynthesis efficiency and accumulation of biomass. This work aims to synthesize and identify strigolactone mimics that promote photosynthesis and biomass accumulation in microalgae with biotechnological potential.

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Despite the substantial decrease in mortality rates following a pancreaticoduodenectomy to less than 5%, morbidity rates remain significant, reaching even 73%. Postoperative pancreatic fistula is one of the most frequent major complications and is significantly associated with other complications, including patient death. Currently, there is no consensus regarding the ideal type of pancreatic anastomosis, as the question of the choice between a pancreaticogastrostomy and pancreaticojejunostomy is still open.

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