Publications by authors named "C Doughty"
Chronic low-grade inflammation observed in older adults, termed inflammaging, is a common feature underlying a multitude of aging-associated maladies including a decline in hematopoietic activity. However, whether suppression of inflammaging can preserve hematopoietic health span remains unclear, in part because of a lack of tools to measure inflammaging within hematopoietic stem cells (HSCs). Here, we identify thrombospondin-1 (Thbs1) as an essential regulator of inflammaging within HSCs.
View Article and Find Full Text PDFPurpose Of Review: Peripheral neuropathy (PN) is more commonly seen in individuals with monoclonal gammopathies, especially in patients with an IgM monoclonal gammopathy or Waldenström macroglobulinemia.
Recent Findings: There are multiple potential ways that the paraprotein may result in peripheral neuropathy. The diagnosis and management of monoclonal gammopathy-associated PN are challenging and necessitate a concerted effort between the hematologist/oncologist and the neurologist.
Background And Aims: Tropical forests exchange more carbon dioxide (CO2) with the atmosphere than any other terrestrial biome. Yet, uncertainty in the projected carbon balance over the next century is roughly three-times greater for the tropics than other ecosystems. Our limited knowledge of tropical plant physiological responses, including photosynthetic, to climate change is a substantial source of uncertainty in our ability to forecast the global terrestrial carbon sink.
View Article and Find Full Text PDFArticle Synopsis
- Plants' survival and adaptation to environmental changes depend on their genetic traits and ability to adjust, but measuring these factors on a large scale is challenging.
- Using a handheld spectrometer, researchers studied the leaf reflectance of the Populus fremontii species across different climates and gardens to detect genetic variations among populations.
- The study found that genetic differences influenced leaf spectra significantly, with unique adjustments made by populations in response to environmental stresses, highlighting the importance of genetic identity for predicting plant responses to climate change.
- Additionally, transferring plants to hotter environments diminished their photosynthetic efficiency, indicating a need for local adaptation to the specific climate.
Intensive leaf cooling promotes tree survival during a record heatwave.
Proc Natl Acad Sci U S A
October 2024
Increasing heatwaves are threatening forest ecosystems globally. Leaf thermal regulation and tolerance are important for plant survival during heatwaves, though the interaction between these processes and water availability is unclear. Genotypes of the widely distributed foundation tree species were studied in a controlled common garden during a record summer heatwave-where air temperature exceeded 48 °C.
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