Generation of induced pluripotent stem cells from ADHD patients who do or do not respond to Methylphenidate treatment.

As a neurodevelopmental multifactorial disorder whose prevalence has been increasing worldwide, attention-deficit hyperactivity disorder (ADHD) is considered a public health concern. Methylphenidate (MPH) is the drug of choice for ADHD; however, not all patients respond fully to this treatment. Therefore, exploring the underlying molecular mechanisms involved in ADHD and potential novel therapeutic targets is crucial.

Epigenetic profiling of prostate cancer reveals potential prognostic signatures.

Purpose: While epigenetic profiling discovered biomarkers in several tumor entities, its application in prostate cancer is still limited. We explored DNA methylation-based deconvolution of benign and malignant prostate tissue for biomarker discovery and the potential of radiomics as a non-invasive surrogate.

Methods: We retrospectively included 30 patients (63 [58-79] years) with prostate cancer (PCa) who had a multiparametric MRI of the prostate before radical prostatectomy between 2014 and 2019.

Crystal structures of seven gold(III) complexes of the form Au ( = substituted pyridine, = Cl or Br).

The structures of seven gold(III) halide derivatives of general formula Au ( = methyl-pyridines or di-methyl-pyridines, = Cl or Br) are presented: tri-chlorido-(2-methyl-pyridine)-gold(III), [AuCl(CHN)], (as two polymorphs and ); tri-bromido-(2-methyl-pyridine)-gold(III), [AuBr(CHN)], ; tri-bromido-(3-methyl-pyridine)-gold(III), [AuBr(CHN)], ; tri-bromido-(2,4-di-meth-yl-pyridine)-gold(III), [AuBr(CHN)], ; tri-chlorido-(3,5-di-methylpyridine)-gold(III), [AuCl(CHN)], ; tri-bromido-(3,5-di-methyl-pyridine)-gold(III), [AuBr(CHN)], , and tri-chlorido-(2,6-di-methyl-pyridine)-gold(III), [AuCl(CHN)], . Additionally, the structure of , the 1:1 adduct of and , [AuBr(CHN)]·[AuBr(CHN)], is included. All the structures crystallize solvent-free, and all have ' = 1 except for and , which display crystallographic twofold rotation symmetry, and , which has ' = 2.

Histopathologic, Molecular, and Clinical Profiling of Lymphoepithelioma-like Carcinoma of the Bladder.

Lymphoepithelioma-like carcinoma of the bladder (LELC-B) is a rare histologic subtype characterized by strong immune cell (IC) infiltrates. A better prognosis and favorable response rates to immune checkpoint inhibitors have been described. We aimed to characterize the molecular profiles and IC infiltration of LELC-B for a better understanding of its therapeutic implications.