Publications by authors named "C Donzelli"
Unlabelled: The primary treatment for glioblastoma (GBM) is removing the tumor mass as defined by MRI. However, MRI has limited diagnostic and predictive value. Tumor-associated macrophages (TAM) are abundant in GBM tumor microenvironment (TME) and are found in peripheral blood (PB).
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- * The majority of burns were caused by hot liquids (79%), with a mean total burn surface area of 14%, and most injuries were classified as second-degree (79%).
- * A comprehensive, multidisciplinary approach to treatment and prevention is recommended, as the study found no significant risks of additional infections from concurrent SARS-CoV-2 in burn patients.
: Ever since the discovery of tumor-associated immune cells, there has been growing interest in the understanding of the mechanisms underlying the crosstalk between these cells and tumor cells. A "seed and soil" approach has been recently introduced to describe the glioblastoma (GBM) landscape: tumor microenvironments act as fertile "soil" and interact with the "seed" (glial and stem cells compartment). In the following article, we provide a systematic review of the current evidence pertaining to the characterization of glioma-associated macrophages and microglia (GAMs) and microglia and macrophage cells in the glioma tumor microenvironment (TME).
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- Advanced cervical cancer has a poor prognosis, but a study of cervical cancer cell lines identified key mutations and genetic patterns that could inform treatment.
- Researchers found somatic mutations in 22 genes and widespread mutations linked to the APOBEC enzyme, focusing on pathways like ERBB2 and PI3K.
- Drug testing revealed that combining PIK3CA and pan-HER inhibitors showed promising results in shrinking tumors with specific genetic alterations, indicating potential new treatment strategies for patients.