Publications by authors named "C Donohue"

Understanding "how to optimize the production of scientific knowledge" is paramount to those who support scientific research-funders as well as research institutions-to the communities served, and to researchers. Structured archives can help all involved to learn what decisions and processes help or hinder the production of new knowledge. Using artificial intelligence (AI) and large language models (LLMs), we recently created the first structured digital representation of the historic archives of the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health.

View Article and Find Full Text PDF

Objectives: Limited normative reference data are available for validated outcomes of flexible endoscopic evaluation of swallowing (FEES). We aimed to examine healthy swallowing via FEES in community-dwelling healthy adults to derive a preliminary reference dataset of normative validated FEES outcomes to guide clinical interpretation and diagnostic decision-making.

Methods: Adults with no history of dysphagia-related disease underwent simultaneous videofluoroscopy and FEES imaging using a standardized 11-item bolus protocol.

View Article and Find Full Text PDF

Care for the patient with diabetic foot ulcers (DFUs) entails understanding the epidemiology, pathophysiology, and a systematic approach to diagnosis and treatment. The authors will review elements of DFU in geriatric patients including the pathophysiology of diabetes, epidemiology and management of DFU in the context of developing a Plan for Healing. The authors will discuss comprehensive principles of a Plan for Healing, which applies to all aspects of chronic wounds.

View Article and Find Full Text PDF
Article Synopsis
  • - The study examined how cardiac surgery affects swallowing safety and vocal fold mobility in 35 adults by performing evaluations before and after the surgery, revealing a significant increase in unsafe swallowing postoperatively.
  • - Results showed that only 14% of patients had safe swallowing post-surgery, compared to 60% pre-surgery, indicating a concerning rise in aspiration and penetration occurrences.
  • - Despite the increase in aspiration rates, no cases of vocal fold paralysis were detected, underscoring the need for more regular laryngoscopic examinations after surgery to monitor these conditions.
View Article and Find Full Text PDF

Introduction/aims: Evaluations of pulmonary, cough, and swallow function are frequently performed to assess disease progression in amyotrophic lateral sclerosis (ALS), yet the relationship between these functions remains unknown. We therefore aimed to determine relationships between these measures in individuals with ALS.

Methods: One hundred individuals with ALS underwent standardized tests: forced vital capacity (FVC), maximum expiratory/inspiratory pressure (MEP, MIP), voluntary cough peak expiratory flow (PEF), and videofluoroscopic swallow evaluation (VF).

View Article and Find Full Text PDF