[High anti-topoisomerase-1 autoantibodies levels are associated with the extension of skin fibrosis and vascular progression in patients with systemic sclerosis].

Background: Anti-centromere antibodies, anti-topoisomerase-1 antibodies (ATA), and anti-RNA-polymerase III antibodies are three Systemic Sclerosis (SSc)-specific autoantibodies. Their detection is helpful in determining the prognosis. We aimed to evaluate whether ATA levels were associated with disease severity at diagnosis or disease progression during follow-up in ATA positive patients.

Modulating lifetimes and relaxation times of phenoxyl radicals through their incorporation into different hybrid nanostructures.

The development of new open shell systems is essential for advances in spin science. In this work, we report the synthesis and characterization of three nanostructured materials, namely SBA-15 silicas, periodic mesoporous organosilicas (PMOs) and lamellar polysilsesquioxanes, all functionalized with the same diazene-based phenoxyl radical precursor. The impact of the nature of the material, i.

Diazene-Functionalized Lamellar Materials as Nanobuilding Blocks: Application as Light-Sensitive Fillers to Initiate Radical Photopolymerizations.

New polysilsesquioxane-based lamellar materials, functionalized with radical precursors, were synthesized. They play a double role in the preparation of composite materials: first, as filler homogeneously dispersed in the monomer after delamination, second as radical initiator in photopolymerization. These polysilsesquioxanes enable fast and efficient photopolymerization upon UV light for thick samples.

Drosophila muller f elements maintain a distinct set of genomic properties over 40 million years of evolution.

The Muller F element (4.2 Mb, ~80 protein-coding genes) is an unusual autosome of Drosophila melanogaster; it is mostly heterochromatic with a low recombination rate. To investigate how these properties impact the evolution of repeats and genes, we manually improved the sequence and annotated the genes on the D.