Publications by authors named "C Doderer"
Background: The risk of malaria transmission by blood transfusion is critical due to extensive travel from endemic areas to non-endemic areas. An enzyme-linked immunosorbent assay (ELISA) malaria antibody test has been developed that is claimed to perform better than the immunofluorescence assay test (IFAT). The assay contains antigens to both Plasmodium falciparum and Plasmodium vivax.
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- The study aimed to evaluate a new ELISA test kit, DiaMed, for malaria antibodies, comparing its sensitivity and specificity against the gold standard Indirect Fluorescence Antibody Test (IFAT).
- The results showed that the DiaMed ELISA had a clinical sensitivity of 84.2% and specificity of 99.6%, outperforming IFAT in detecting P. vivax infections.
- Although DiaMed ELISA demonstrated strong overall analytical performance, further studies are necessary to validate its effectiveness in blood bank environments.
Background: Strong and stable transgene expression is fundamental to the success of recombinant adenovirus vectors in human gene therapy. However, control of transgene expression is a complex process, involving both viral and cellular factors. In this study, the influence of the E4 adenoviral region on the activity of various promoters was investigated in vitro and in vivo.
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