Publications by authors named "C Diez-Planelles"
Article Synopsis
- The study investigates how long-term resistance and endurance training affect the epigenomic and transcriptomic changes in the hippocampus of mice.
- Using techniques like whole-genome bisulfite sequencing and RNA sequencing, researchers analyze these effects after 4 weeks of training and assess cognitive improvements through a novel object recognition test.
- Findings show different training models influence DNA methylation and gene expression pathways, highlighting endurance training's connection to neuroplasticity and resistance training's role in interferon responses, both linked to enhanced learning and memory.
Endurance training promotes exercise-induced adaptations in brain, like hippocampal adult neurogenesis and autophagy induction. However, resistance training effect on the autophagy response in the brain has not been much explored. Questions such as whether partial systemic autophagy or the length of training intervention affect this response deserve further attention.
View Article and Find Full Text PDFHuntington's disease (HD) is a hereditary neurodegenerative disease, with peripheral consequences that negatively contribute to quality of life. Circulating microRNAs (cmiRNAs) are being explored for their roles in intercellular communication and gene expression regulation, which allows gaining insight into the regulation of crosstalk between neuronal and peripheral tissues. Here, we explore the cmiRNA profile of plasma samples from fifteen symptomatic patients, with 40-45 CAG repeats in the HTT gene, and seven healthy matched controls.
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