Publications by authors named "C Diaz de la Guardia"
Article Synopsis
- Sexual reproduction, while beneficial for creating offspring, comes with significant costs and challenges, particularly during pregnancy.*
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- Autophagy, a vital process controlled by specific genes, plays a key role in managing metabolic stress throughout pregnancy in viviparous eukaryotes.*
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- The review highlights the importance of autophagy in reproduction and its potential impact on pregnancy disorders like preterm birth and preeclampsia, suggesting it could be a target for future therapies.*
EMBO Mol Med
January 2025
Article Synopsis
- Brain development involves the coordinated growth of structures necessary for forming neural circuits, with the corpus callosum being a crucial connection between brain hemispheres.
- Defects in the growth process, particularly in the development of callosal projection neurons, can lead to syndromic corpus callosum dysgenesis (CCD) and are associated with other conditions like microcephaly.
- The study identifies WDR47 as a key gene responsible for survival of callosal neurons and highlights its role in mitochondrial and microtubule maintenance, suggesting that mutations in this gene lead to a new neurodevelopmental syndrome involving corpus callosum abnormalities.
J Cosmet Dermatol
November 2024
Article Synopsis
- The study evaluated the safety and effectiveness of the dermal filler VYC-17.5 L for treating marionette lines in adults over a 12-month period.
- Nearly 70% of participants showed improvement in marionette lines, with significant enhancements noted in overall facial appearance and satisfaction scores.
- Most side effects were mild and resolved quickly, indicating that VYC-17.5 L is an effective and well-tolerated treatment option for this aging feature.
J Cosmet Dermatol
November 2024
Article Synopsis
- VYC-25L is a hyaluronic acid filler approved in 2019 for facial volumizing, lifting, and contouring, offering a long-lasting effect of at least 24 months.
- Experienced doctors highlight its unique properties, including high lift capacity, moldability, and tissue integration, which enhance its use in non-surgical facial aesthetics.
- Proper technique and cautious application are essential for maximizing patient benefits, including starting with the chin and jawline and following best practice principles to ensure safety and effectiveness.
ESC Heart Fail
October 2024
Article Synopsis
- Cardiogenic shock (CS) poses significant health risks, necessitating effective interventions to maintain blood pressure and tissue perfusion, while current treatments, like inotropes, can lead to serious side effects.
- The SEISMiC study aims to evaluate the safety and effectiveness of istaroxime, a new drug that may improve blood flow without overstimulating adrenergic receptors, in patients at risk for CS.
- This multinational, double-blind study involves patients with severe heart failure and aims to measure the drug's impact on blood pressure and other cardiac metrics over a 60-hour period, aiming to clarify istaroxime's potential benefits in managing pre-CS conditions.
