Publications by authors named "C Di Primio"
Introduction: Recent research revealed that Tau plays critical roles in various neuronal functions. We previously demonstrated that destabilization and nuclear delocalization of Tau alter the expression of glutamatergic genes, mediating early neuronal damage.
Methods: In this study, we discovered that changes in Tau availability are linked to global alterations in gene expression that affect multiple neuronal pathways.
Article Synopsis
- The study investigates which polygenic scores (PGSs) for coronary artery disease (CAD) are most effective in identifying high-risk individuals within the Italian population, highlighting the need for tailored genetic risk assessment tools.
- Using data from two independent Italian cohorts, the researchers analyzed 266 PGSs and found that 49 of them showed significantly different distributions between CAD patients and controls, with PGS003727 being the most accurate.
- The findings suggest that existing European CAD PGSs may not be uniformly applicable across different populations, emphasizing the importance of further validation for clinical use in specific regions like Italy.
Article Synopsis
- - The study investigates the relationship between SARS-CoV-2 infection and adipocytes (fat cells) using the SGBS human cell line, highlighting that excess fat mass may increase the risk of severe COVID-19.
- - Findings show that adipocytes can be infected by SARS-CoV-2, leading to the release of viral particles and significant changes in cell structure and function, such as increased inflammation and altered lipid metabolism.
- - The research concludes that SARS-CoV-2 infection causes notable morphological and functional modifications in adipocytes, possibly affecting the progression and severity of COVID-19.
Purinergic receptors and NOD-like receptor protein 3 (NLRP3) inflammasome regulate inflammation and viral infection, but their effects on severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection remain poorly understood. Here, we report that the purinergic receptor P2X7 and NLRP3 inflammasome are cellular host factors required for SARS-CoV-2 infection. Lung autopsies from patients with severe coronavirus disease 2019 (COVID-19) reveal that NLRP3 expression is increased in host cellular targets of SARS-CoV-2 including alveolar macrophages, type II pneumocytes and syncytia arising from the fusion of infected macrophages, thus suggesting a potential role of NLRP3 and associated signaling pathways to both inflammation and viral replication.
View Article and Find Full Text PDFCOVID-19 has represented an issue for global health since its outbreak in March 2020. It is now evident that the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection results in a wide range of long-term neurological symptoms and is worryingly associated with the aggravation of Alzheimer's disease. Little is known about the molecular basis of these manifestations.
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