Publications by authors named "C Denz"

Article Synopsis
  • Inhibiting CDK4/6 kinases has improved breast cancer outcomes, but only a small number of patients achieve long-term control of the disease.
  • The study finds that loss of the TP53 gene and amplification of the MDM2 gene are linked to poor long-term outcomes in patients with metastatic hormone receptor-positive breast cancer.
  • In laboratory models, losing p53 does not impact CDK4/6 activity but leads to changes in CDK2 that allow cancer cells to evade treatment, suggesting a need for combined inhibition of CDK4/6 and CDK2 for better responses in diverse cases of HR+ breast cancer.
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In this article, we demonstrate the fabrication of 3D cell-like structures using a femtosecond laser-based two-photon polymerization technique. By employing poly(ethylene glycol) diacrylate monomers as a precursor solution, we fabricate 3D hemispheres that resemble morphological and biomechanical characteristics of natural cells. We employ an optical tweezers-based microrheology technique to measure the viscoelastic properties of the precursor solutions inside and outside the structures.

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Flat band systems are commonly associated with compact localized states (CLSs) that arise from the macroscopic degeneracy of eigenstates at the flat band energy. However, in the case of singular flat bands, conventional localized flat band states are incomplete, leading to the existence of noncontractible loop states (NLSs) with nontrivial real-space topology. In this study, we experimentally and analytically demonstrate the existence of NLSs in a 2D photonic borophene lattice without a CLS counterpart, owing to a band that is flat only along high-symmetry lines and dispersive along others.

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Controlling random light is a key enabling technology that pioneered statistical imaging methods like speckle microscopy. Such low-intensity illumination is especially useful for bio-medical applications where photobleaching is crucial. Since the Rayleigh intensity statistics of speckles do not always meet the requirements of applications, considerable effort has been dedicated to tailoring their intensity statistics.

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