Publications by authors named "C Demeilliers"
Article Synopsis
- Polycyclic aromatic hydrocarbons (PAHs), especially benzo(a)pyrene (B(a)P), are harmful environmental contaminants linked to serious health issues like cancer and immune system suppression.
- This study investigates the use of extracellular vesicles (EVs) and their microRNA (miRNA) content as potential biomarkers for PAH exposure, focusing on changes in EV production and miRNA profiles following exposure to B(a)P.
- The findings show that B(a)P exposure increases EV production and specifically regulates the expression of miR-342-3p, suggesting that EVs and miRNAs could serve as valuable indicators of PAH exposure in toxicological assessments.
Dominant optic atrophy is an optic neuropathy with varying clinical symptoms and progression. A severe disorder is associated with certain OPA1 mutations and includes additional symptoms for >20% of patients. This underscores the consequences of OPA1 mutations in different cellular populations, not only retinal ganglionic cells.
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- * This study aimed to explore how B[a]P affects the expression of certain microRNAs (miRNAs) in PBMCs, using techniques like small RNA deep sequencing to identify miRNAs that respond to B[a]P exposure.
- * The research found that the miRNA miR-132 is significantly induced by B[a]P in a time- and dose-dependent manner, suggesting it plays a role in regulating cell death mechanisms linked to these
Background: Asphalt road paving and its subsequent complex airborne emissions have raised concerns about occupational exposures and environmental impacts. Although several studies described bitumen fumes or Polycyclic Aromatic Hydrocarbons (PAH) emissions at specific worksites, no comprehensive studies have characterised road paving emissions and identified the main determinants of exposure.
Methods: A 10-year study from 2012 to 2022 was performed to examine the pollutants resulting from bitumen fume emissions and covering the main processes used in road paving (asphalt production, mechanical rolled asphalt paving, manual paving, mastic asphalt paving, emulsion paving, and coal-tar asphalt milling).