Individuals, families, and communities are impacted by Alzheimer's disease and other dementias worldwide. In Canada and elsewhere, family members commonly see loved ones living with dementia experience difficult moments, including anxiety, stress, and fear. Struggling health care systems strive to apply the latest evidence-based interventions.
View Article and Find Full Text PDFJ Psychiatr Ment Health Nurs
September 2024
Lymph nodes and other secondary lymphoid organs play critical roles in immune surveillance and immune activation in mammals, but the deep internal locations of these organs make it challenging to image and study them in living animals. Here, we describe a previously uncharacterized external immune organ in the zebrafish ideally suited for studying immune cell dynamics , the axillary lymphoid organ (ALO). This small, translucent organ has an outer cortex teeming with immune cells, an inner medulla with a mesh-like network of fibroblastic reticular cells along which immune cells migrate, and a network of lymphatic vessels draining to a large adjacent lymph sac.
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