Publications by authors named "C Delaugerre"
Article Synopsis
- Surveillance of Transmitted Drug Resistance (TDR) is essential for understanding the changes in HIV trends, with a focus on multiple types of antiretroviral drugs and new treatments.
- A study involving 85 individuals diagnosed with primary HIV-1 infection (PHI) from 2020 to 2023 analyzed genetic sequences to identify TDR and its impact on drug resistance, revealing varying levels of resistance to several drug classes.
- The findings highlight the importance of monitoring TDR at the onset of HIV infection to improve treatment strategies and the effectiveness of pre-exposure prophylaxis (PrEP) with newer drug options.
Article Synopsis
- - The study examined cytomegalovirus (CMV) risk factors in men who have sex with men, focusing on participants in the HIV pre-exposure prophylaxis trial IPERGAY-ANRS.
- - Of the 417 participants, 382 were already CMV positive, showing a high prevalence rate of 91.6%, and 10 new cases were identified during the study.
- - Findings suggest that having many sexual partners increases the likelihood of CMV, with shedding observed in participants who seroconverted.
Article Synopsis
- This study investigates the immune response to SARS-CoV-2 after COVID-19 infection and vaccination, focusing on anti-RBD antibodies and functional neutralizing antibodies (NAbs).
- Researchers analyzed samples from different groups, including partially and fully vaccinated individuals as well as those who had COVID-19 with or without vaccination, using advanced testing methods.
- Results showed that the post-COVID/vaccination group had the strongest immune protection, with a clear link between antibody levels and neutralization ability, and the ichroma™ test proved effective in assessing immunity.
Article Synopsis
- The study evaluates a new ultrasensitive test for Hepatitis B, called HBsAg Next (HBsAgNx), which is significantly more sensitive than current tests, making it crucial for accurate diagnosis and monitoring.
- Researchers analyzed 253 samples and found that HBsAgNx had a strong agreement with traditional testing methods while detecting cases that were missed by the older assays, including instances of occult HBV infection.
- The findings suggest that HBsAgNx offers better sensitivity and specificity, which may improve clinical outcomes by enabling earlier detection of infections and monitoring of reactivations in patients.
Pre-exposure prophylaxis (PrEP) of human immunodeficiency virus (HIV) represents the most significant breakthrough in the HIV prevention field over the past decade. PrEP is an effective strategy in preventing the transmission of HIV across all populations, providing high adherence. The current PrEP options include oral daily and on-demand tenofovir-based regimens, long-acting injections of cabotegravir, and a 1-month dapivirine vaginal ring.
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