Publications by authors named "C Del Borgo"
Chronic myeloid leukemia (CML) is characterized by the fusion protein BCR::ABL1, a constitutively active tyrosine kinase. The frontline treatment, represented by tyrosine kinase inhibitors (TKIs), has dramatically improved the clinical outcomes of patients. However, TKI resistance through various mechanisms has been reported.
View Article and Find Full Text PDFObjectives: To estimate the risk of COVID-19-related hospitalization and death (CovH/D), among high-risk individuals early treated for COVID-19 and to identify associated factors.
Methods And Results: A multicenter cohort of 12,475 high-risk outpatients (female 50.2%, median age 70 years [IQR 57-80], fully vaccinated 79.
Following viral infection, antigen-restricted T lymphocytes are activated and recognize infected cells to eliminate them. A subset of T cells differentiates into memory lymphocytes able to counteract viral rechallenge in a faster and enhanced way. SARS-CoV-2 can escape immune responses leading to a poor clinical outcome.
View Article and Find Full Text PDFArticle Synopsis
- Low-grade endotoxemia, caused by lipopolysaccharide (LPS), is detected in COVID-19 patients, potentially promoting thrombosis through a pro-inflammatory and pro-coagulant state.
- The study measured various biomarkers in 175 COVID-19 patients and 50 healthy controls, finding significantly elevated levels of markers like sNOX2-dp and D-dimer in COVID-19 patients, especially those with acute respiratory distress syndrome (ARDS).
- Results suggest that factors like impaired gut barrier function, high NOX2 activation, and low albumin may lead to low-grade endotoxemia, increasing the risk of thrombotic events in COVID-19 patients.
Article Synopsis
- COVID-19 is associated with abnormal levels of specific cytokines in the body, which may help in managing the disease.
- The study measures various inflammatory cytokines in serum samples from healthy individuals, COVID-19 patients upon hospital admission, and those who have recovered after different timeframes.
- Results showed that IL-10 levels rise during initial infection, while other cytokines like IL-27 and TNF-α fluctuate over time, suggesting that some cytokines may indicate disease severity or the risk of long-term effects after recovery.